Doctors and Nurses have critical roles and responsibilities during the COVID-19 pandemic. They will continue to be at the front line of patient care in hospitals and actively involved with evaluation and monitoring in the community. Nurses have to ensure that all patients acquire personalized, high-quality services irrespective of their infectious condition. They will also engage in planning for anticipated COVID-19–related outbreaks, which increase the demand for nursing and healthcare services that might overload systems. Moreover, nurses must maintain effective supply and usage of sanitation materials and personal protective equipment and offer screening information, confinement guidelines, and triage protocols based on the latest guidance. A global pandemic needs strong nursing staff engagement in clinical management, awareness and knowledge exchange, and public safety.